產(chǎn)品詳情
簡單介紹：
Anti-ACSS1 antibody (340-689) (STJ117203)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ACSS1 (340-689) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACSS1 |
| Gene ID: | 84532 |
| Uniprot ID: | ACS2L_HUMAN |
| Immunogen Region: | 340-689 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 340-689 of human ACSS1 (NP_115890.2). |
| Immunogen Sequence: | ITGHSYVVYGPLCNGATSVL FESTPVYPNAGRYWETVERL KINQFYGAPTAVRLLLKYGD AWVKKYDRSSLRTLGSVGEP INCEAWEWLHRVVGDSRCTL VDTWWQTETGGICIAPRPSE EGAEILPAMAMRPFFGIVPV LMDEKGSVVEGSNVSGALCI SQAWPGMARTIYGDHQRFVD AYFKAYPGYYFTGDGAYRTE GGYYQITGRMDDVINISGHR LGTAEIEDAIADHPAVPES |
| Post Translational Modifications | Reversibly acetylated on Lys-642. The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylase SIRT3. |
| Function | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient. |
| Protein Name | Acetyl-Coenzyme A Synthetase 2-Like - Mitochondrial Acetate--Coa Ligase 2 Acetyl-Coa Synthetase 2 Acecs2 Acyl-Coa Synthetase Short-Chain Family Member 1 Propionate--Coa Ligase |
| Database Links | Reactome: R-HSA-71384 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Acetyl-Coenzyme A Synthetase 2-Like - Mitochondrial antibody Anti-Acetate--Coa Ligase 2 antibody Anti-Acetyl-Coa Synthetase 2 antibody Anti-Acecs2 antibody Anti-Acyl-Coa Synthetase Short-Chain Family Member 1 antibody Anti-Propionate--Coa Ligase antibody Anti-ACSS1 antibody Anti-ACAS2L antibody Anti-KIAA1846 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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