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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human CTLA-4/CD152 protein (Recombinant) (C-His) (STJP002690)

  • 產(chǎn)品型號：STJP002690
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human CTLA-4/CD152 protein (Recombinant) (C-His) (STJP002690)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CTLA-4/CD152-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized lpilimumab at 1 Mu g/mL (100 Mu L/well) can bind Recombinant Human CTLA-4 with a linear range of 6-18 ng/mL.2.Measured by its binding ability in a functional ELISA.Immobilized PE anti
Gene Symbol: CTLA4
Gene ID: 1493
Uniprot ID: CTLA4_HUMAN
Immunogen Region: Ala37-Phe162
Immunogen: Recombinant Human CTLA-4/CD152 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala37-Phe162) of human CTLA-4 (Accession #NP_005205.2) fused with a 6×His tag at the C-terminus.
Post Translational Modifications N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
Function Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Protein Name Cytotoxic T-Lymphocyte Protein 4
Cytotoxic T-Lymphocyte-Associated Antigen 4
Ctla-4
Cd Antigen Cd152
Database Links Reactome: R-HSA-389513
Reactome: R-HSA-8877330
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Exists Primarily An Intracellular Antigen Whose Surface Expression Is Tightly Regulated By Restricted Trafficking To The Cell Surface And Rapid Internalization
Alternative Protein Names Cytotoxic T-Lymphocyte Protein 4 protein
Cytotoxic T-Lymphocyte-Associated Antigen 4 protein
Ctla-4 protein
Cd Antigen Cd152 protein
CTLA4 protein
CD152 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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