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產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：Human CTLA-4/CD152 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002139)

  • 產(chǎn)品型號(hào)：STJP002139-100
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Human CTLA-4/CD152 protein (Recombinant) (C-His & Avi) {Biotin} (STJP002139)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CTLA-4/CD152-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CTLA4
Gene ID: 1493
Uniprot ID: CTLA4_HUMAN
Immunogen Region: Ala37-Asp161
Immunogen: Biotinylated Recombinant Human CTLA4 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ala37-Asp161) of Human CTLA4 fused with His tag and Avi tag at the C-terminal.
Post Translational Modifications N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
Function Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Protein Name Cytotoxic T-Lymphocyte Protein 4
Cytotoxic T-Lymphocyte-Associated Antigen 4
Ctla-4
Cd Antigen Cd152
Database Links Reactome: R-HSA-389513
Reactome: R-HSA-8877330
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Exists Primarily An Intracellular Antigen Whose Surface Expression Is Tightly Regulated By Restricted Trafficking To The Cell Surface And Rapid Internalization
Alternative Protein Names Cytotoxic T-Lymphocyte Protein 4 protein
Cytotoxic T-Lymphocyte-Associated Antigen 4 protein
Ctla-4 protein
Cd Antigen Cd152 protein
CTLA4 protein
CD152 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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