產(chǎn)品詳情
簡單介紹：
Human Cripto-1/TDGF1 protein (Recombinant) (C-His) (STJP002599)
詳情介紹：
| Host: | HEK293 cells |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Recombinant-Human Cripto-1/TDGF1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: | Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Cripto at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human ALK4 with a linear range of 0.15-151 ng/mL. |
| Gene Symbol: | CRIPTO |
| Gene ID: | 6997 |
| Uniprot ID: | TDGF1_HUMAN |
| Immunogen Region: | Leu31-Thr172 |
| Immunogen: | Recombinant Human Cripto-1/TDGF1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu31-Thr172) of human Cripto/TDGF1 (Accession #NP_003203) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing CRIPTO as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form. |
| Function | GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. |
| Protein Name | Protein Cripto Cripto - Egf-Cfc Family Member Cripto-1 Growth Factor Crgf Epidermal Growth Factor-Like Cripto Protein Cr1 Teratocarcinoma-Derived Growth Factor 1 |
| Database Links | Reactome: R-HSA-1181150 Reactome: R-HSA-1433617 Reactome: R-HSA-2892247 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Secreted Released From The Cell Membrane By Gpi Cleavage |
| Alternative Protein Names | Protein Cripto protein Cripto - Egf-Cfc Family Member protein Cripto-1 Growth Factor protein Crgf protein Epidermal Growth Factor-Like Cripto Protein Cr1 protein Teratocarcinoma-Derived Growth Factor 1 protein CRIPTO protein CRIPTO-1 protein TDGF1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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