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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ACKR1 antibody (1-50 aa) (STJ92785)

  • 產(chǎn)品型號：STJ92785
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-ACKR1 antibody (1-50 aa) (STJ92785)
詳情介紹：
Host: Rabbit
Applications: IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Atypical chemokine receptor 1 (1-50 aa) is suitable for use in Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IF 1:200-1:1000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACKR1
Gene ID: 2532
Uniprot ID: ACKR1_HUMAN
Immunogen Region: 1-50 aa
Specificity: Duffy Polyclonal Antibody detects endogenous levels of Duffy protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human DARC at the amino acid range 1-50
Function Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes.when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Protein Name Atypical Chemokine Receptor 1
Duffy Antigen/Chemokine Receptor
Fy Glycoprotein
Gpfy
Glycoprotein D
Plasmodium Vivax Receptor
Cd Antigen Cd234
Database Links Reactome: R-HSA-375276
Cellular Localisation Early Endosome
Recycling Endosome
Membrane
Multi-Pass Membrane Protein
Predominantly Localizes To Endocytic Vesicles
And Upon Stimulation By The Ligand Is Internalized Via Caveolae
Once Internalized
The Ligand Dissociates From The Receptor
And Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane
Alternative Antibody Names Anti-Atypical Chemokine Receptor 1 antibody
Anti-Duffy Antigen/Chemokine Receptor antibody
Anti-Fy Glycoprotein antibody
Anti-Gpfy antibody
Anti-Glycoprotein D antibody
Anti-Plasmodium Vivax Receptor antibody
Anti-Cd Antigen Cd234 antibody
Anti-ACKR1 antibody
Anti-DARC antibody
Anti-FY antibody
Anti-GPD antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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