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產品名稱：Anti-Acetyl-XRCC5-Lys565 antibody (STJ193231)
產品型號：STJ193231
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-Acetyl-XRCC5-Lys565 antibody (STJ193231)

詳情介紹：

Host:	Rabbit
Applications:	IHC/IF/WB
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Acetyl-X-ray repair cross-complementing protein 5-Lys565 is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC-P 1:50-200 WB 1:500-2000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	XRCC5
Gene ID:	7520
Uniprot ID:	XRCC5_HUMAN
Specificity:	This antibody detects endogenous acetyl levels of Ku-80 (Acetyl-Lys565) at Human:K565
Immunogen:	Synthesized peptide derived from the human Ku-80 (Acetyl-Lys565)

Function	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection. Binding to DNA may be mediated by XRCC6. The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription. In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome. Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Protein Name	X-Ray Repair Cross-Complementing Protein 5 86 Kda Subunit Of Ku Antigen Atp-Dependent Dna Helicase 2 Subunit 2 Atp-Dependent Dna Helicase Ii 80 Kda Subunit Ctc Box-Binding Factor 85 Kda Subunit Ctc85 Ctcbf Dna Repair Protein Xrcc5 Ku80 Ku86 Lupus Ku Autoantigen Protein P86 Nuclear Factor Iv Thyroid-Lupus Autoantigen Tlaa X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 5 Double-Strand-Break Rejoining
Database Links	Reactome: R-HSA-164843 Reactome: R-HSA-1834949 Reactome: R-HSA-3270619 Reactome: R-HSA-5693571 Reactome: R-HSA-6798695
Cellular Localisation	Nucleus Nucleolus Chromosome
Alternative Antibody Names	Anti-X-Ray Repair Cross-Complementing Protein 5 antibody Anti-86 Kda Subunit Of Ku Antigen antibody Anti-Atp-Dependent Dna Helicase 2 Subunit 2 antibody Anti-Atp-Dependent Dna Helicase Ii 80 Kda Subunit antibody Anti-Ctc Box-Binding Factor 85 Kda Subunit antibody Anti-Ctc85 antibody Anti-Ctcbf antibody Anti-Dna Repair Protein Xrcc5 antibody Anti-Ku80 antibody Anti-Ku86 antibody Anti-Lupus Ku Autoantigen Protein P86 antibody Anti-Nuclear Factor Iv antibody Anti-Thyroid-Lupus Autoantigen antibody Anti-Tlaa antibody Anti-X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 5 antibody Anti-Double-Strand-Break Rejoining antibody Anti-XRCC5 antibody Anti-G22P2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-Acetyl-XRCC5-Lys565 antibody (STJ193231)