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產(chǎn)品詳情

  • 產(chǎn)品名稱：CXCR3 Blocking Peptide for STJ500655 peptide (STJ505277)

  • 產(chǎn)品型號：STJ505277-250
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
CXCR3 Blocking Peptide for STJ500655 peptide (STJ505277)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: CXCR3 Blocking Peptide for STJ500655 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CXCR3
Gene ID: 2833
Uniprot ID: CXCR3_HUMAN
Immunogen Region: 1-50
Specificity: This blocking peptide is recommended for use in combination with CXCR3 antibody, STJ500655
Immunogen: Synthetic peptide taken within amino acid region 1-50 on human CXCR3 protein
Post Translational Modifications Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. N-glycosylated.
Function Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.
Peptide Name C-X-C Chemokine Receptor Type 3
Cxc-R3
Cxcr-3
Ckr-L2
G Protein-Coupled Receptor 9
Interferon-Inducible Protein 10 Receptor
Ip-10 Receptor
Cd Antigen Cd183
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Cellular Localisation Isoform 1: Cell Membrane
Multi-Pass Membrane Protein
Isoform 2: Cell Membrane
Alternative Peptide Names C-X-C Chemokine Receptor Type 3 protein
Cxc-R3 protein
Cxcr-3 protein
Ckr-L2 protein
G Protein-Coupled Receptor 9 protein
Interferon-Inducible Protein 10 Receptor protein
Ip-10 Receptor protein
Cd Antigen Cd183 protein
CXCR3 protein
GPR9 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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