產(chǎn)品詳情
簡單介紹：
Anti-Acetyl-STAT5A-Lys84 antibody (STJA0005997)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Acetyl-Signal transducer and activator of transcription 5A-Lys84 is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-p 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STAT5A |
| Gene ID: | 6776 |
| Uniprot ID: | STA5A_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human, Mouse, Rat Stat5a (Acetyl Lys84) |
| Immunogen: | Synthesized peptide derived from human Stat5a (Acetyl Lys84) |
| Post Translational Modifications | Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity. Tyrosine phosphorylated in response to signaling via activated FLT3.wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-694. ISGylated. |
| Function | Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. |
| Protein Name | Signal Transducer And Activator Of Transcription 5a |
| Database Links | Reactome: R-HSA-1170546 Reactome: R-HSA-1251985 Reactome: R-HSA-1266695 Reactome: R-HSA-1433557 Reactome: R-HSA-1839117 Reactome: R-HSA-186763 Reactome: R-HSA-2586552 Reactome: R-HSA-512988 Reactome: R-HSA-8854691 Reactome: R-HSA-8983432 Reactome: R-HSA-8985947 Reactome: R-HSA-9020558 Reactome: R-HSA-9020958 Reactome: R-HSA-9027283 Reactome: R-HSA-9645135 Reactome: R-HSA-9670439 Reactome: R-HSA-9674555 Reactome: R-HSA-9702518 Reactome: R-HSA-9703465 Reactome: R-HSA-9705462 Reactome: R-HSA-9725371 Reactome: R-HSA-982772 |
| Cellular Localisation | Cytoplasm Nucleus Translocated Into The Nucleus In Response To Phosphorylation |
| Alternative Antibody Names | Anti-Signal Transducer And Activator Of Transcription 5a antibody Anti-STAT5A antibody Anti-STAT5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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