印度肥婆丰满bbw,娇乳欲女h奶汁翘,漂亮人妻办公室里沦陷,日韩Aⅴ人妻无码一区二区

產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-Acetyl-RUNX1-Lys24 antibody (STJA0005919)

  • 產(chǎn)品型號(hào)：STJA0005919
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
你添加了1件商品 查看購(gòu)物車
簡(jiǎn)單介紹：
Anti-Acetyl-RUNX1-Lys24 antibody (STJA0005919)
詳情介紹：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Acetyl-Runt-related transcription factor 1-Lys24 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RUNX1
Gene ID: 861
Uniprot ID: RUNX1_HUMAN
Specificity: This antibody detects endogenous levels of Human, Mouse, Rat RUNX1 (Acetyl Lys24)
Immunogen: Synthesized peptide derived from human RUNX1 (Acetyl Lys24)
Tissue Specificity Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
Post Translational Modifications Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A. Methylated. Phosphorylated in Ser-249 Thr-273 and Ser-276 by HIPK2 when associated with CBFB and DNA. This phosphorylation promotes subsequent EP300 phosphorylation.
Function Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells. Positively regulates the expression of RORC in T-helper 17 cells. Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Isoform AML-1L interferes with the transactivation activity of RUNX1.
Protein Name Runt-Related Transcription Factor 1
Acute Myeloid Leukemia 1 Protein
Core-Binding Factor Subunit Alpha-2
Cbf-Alpha-2
Oncogene Aml-1
Polyomavirus Enhancer-Binding Protein 2 Alpha B Subunit
Pea2-Alpha B
Pebp2-Alpha B
Sl3-3 Enhancer Factor 1 Alpha B Subunit
Sl3/Akv Core-Binding Factor Alpha B Subunit
Database Links Reactome: R-HSA-1912408
Reactome: R-HSA-549127
Reactome: R-HSA-8877330
Reactome: R-HSA-8931987
Reactome: R-HSA-8934593
Reactome: R-HSA-8935964
Reactome: R-HSA-8936459
Reactome: R-HSA-8939236
Reactome: R-HSA-8939242
Reactome: R-HSA-8939243
Reactome: R-HSA-8939245
Reactome: R-HSA-8939246
Reactome: R-HSA-8939247
Reactome: R-HSA-8939256
Reactome: R-HSA-8941333
Reactome: R-HSA-8951936
Reactome: R-HSA-9018519
Reactome: R-HSA-9616222
Reactome: R-HSA-9692916
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Runt-Related Transcription Factor 1 antibody
Anti-Acute Myeloid Leukemia 1 Protein antibody
Anti-Core-Binding Factor Subunit Alpha-2 antibody
Anti-Cbf-Alpha-2 antibody
Anti-Oncogene Aml-1 antibody
Anti-Polyomavirus Enhancer-Binding Protein 2 Alpha B Subunit antibody
Anti-Pea2-Alpha B antibody
Anti-Pebp2-Alpha B antibody
Anti-Sl3-3 Enhancer Factor 1 Alpha B Subunit antibody
Anti-Sl3/Akv Core-Binding Factor Alpha B Subunit antibody
Anti-RUNX1 antibody
Anti-AML1 antibody
Anti-CBFA2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
電話：
您的需求：
 

滬公網(wǎng)安備 31011002002624號(hào)