產(chǎn)品詳情
簡單介紹：
Anti-Acetyl-POLB-Lys72 antibody (STJA0005987)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Acetyl-DNA polymerase beta-Lys72 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POLB |
| Gene ID: | 5423 |
| Uniprot ID: | DPOLB_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human, Mouse, Rat DNA pol Beta (Acetyl Lys72) |
| Immunogen: | Synthesized peptide derived from human DNA pol Beta (Acetyl Lys72) |
| Function | Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase).through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase. |
| Protein Name | Dna Polymerase Beta 5'-Deoxyribose-Phosphate Lyase 5'-Drp Lyase Ap Lyase |
| Database Links | Reactome: R-HSA-110362 Reactome: R-HSA-110373 Reactome: R-HSA-110381 Reactome: R-HSA-5649702 Reactome: R-HSA-5651801 Reactome: R-HSA-5689880 Reactome: R-HSA-73930 |
| Cellular Localisation | Nucleus Cytoplasm Cytoplasmic In Normal Conditions Translocates To The Nucleus Following Dna Damage |
| Alternative Antibody Names | Anti-Dna Polymerase Beta antibody Anti-5'-Deoxyribose-Phosphate Lyase antibody Anti-5'-Drp Lyase antibody Anti-Ap Lyase antibody Anti-POLB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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