產(chǎn)品詳情
簡單介紹：
Anti-Acetyl-MYOD1-Lys99/K102 antibody (STJA0005981)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Acetyl-Myoblast determination protein 1-Lys99/K102 is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-p 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYOD1 |
| Gene ID: | 4654 |
| Uniprot ID: | MYOD1_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human MyoD (Acetyl Lys99/K102) |
| Immunogen: | Synthesized peptide derived from human MyoD (Acetyl Lys99/K102) |
| Post Translational Modifications | Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation. Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function. Ubiquitinated on the N-terminus.which is required for proteasomal degradation. Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity. |
| Function | Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins. |
| Protein Name | Myoblast Determination Protein 1 Class C Basic Helix-Loop-Helix Protein 1 Bhlhc1 Myogenic Factor 3 Myf-3 |
| Database Links | Reactome: R-HSA-525793 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Myoblast Determination Protein 1 antibody Anti-Class C Basic Helix-Loop-Helix Protein 1 antibody Anti-Bhlhc1 antibody Anti-Myogenic Factor 3 antibody Anti-Myf-3 antibody Anti-MYOD1 antibody Anti-BHLHC1 antibody Anti-MYF3 antibody Anti-MYOD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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