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產(chǎn)品詳情

  • 產(chǎn)品名稱：CDKN2A/p14ARF Positive Control peptide (STJ504545)

  • 產(chǎn)品型號：STJ504545-5
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
CDKN2A/p14ARF Positive Control peptide (STJ504545)
詳情介紹：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: CDKN2A/p14ARF Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CDKN2A
Gene ID: 1029
Uniprot ID: ARF_HUMAN
Post Translational Modifications Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardless of the absence of lysine residues. Ubiquitination leads to its proteasomal degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation.
Function Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF: May be involved in regulation of autophagy and caspase-independent cell death.the short-lived mitochondrial isoform is stabilized by C1QBP.
Peptide Name Tumor Suppressor Arf
Alternative Reading Frame
Arf
Cyclin-Dependent Kinase Inhibitor 2a
P14arf
Database Links Reactome: R-HSA-111471
Reactome: R-HSA-2559580
Reactome: R-HSA-2559585
Reactome: R-HSA-3108214
Reactome: R-HSA-3232118
Reactome: R-HSA-6804757
Reactome: R-HSA-69541
Reactome: R-HSA-8941858
Reactome: R-HSA-9645722
Reactome: R-HSA-9646303
Reactome: R-HSA-9646304
Reactome: R-HSA-9759194
Reactome: R-HSA-2559582
Reactome: R-HSA-69231
Reactome: R-HSA-8853884
Reactome: R-HSA-9630791
Reactome: R-HSA-9630794
Reactome: R-HSA-9632697
Reactome: R-HSA-9632700
Cellular Localisation Nucleus
Nucleolus
Nucleoplasm
Isoform Smarf: Mitochondrion
Alternative Peptide Names Tumor Suppressor Arf protein
Alternative Reading Frame protein
Arf protein
Cyclin-Dependent Kinase Inhibitor 2a protein
P14arf protein
CDKN2A protein
CDKN2 protein
MLM protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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