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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human CD44 protein (Recombinant) (C-hFc&His) (STJP001074)

  • 產(chǎn)品型號(hào)：STJP001074
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Human CD44 protein (Recombinant) (C-hFc&His) (STJP001074)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD44-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Hyaluronic Acid at 100 Mu g/mL (100 Mu L/well) can bind Human CD44 with a linear range of 20-330 ng/mL.
Gene Symbol: CD44
Gene ID: 960
Uniprot ID: CD44_HUMAN
Immunogen Region: Gln21-Pro220
Immunogen: Recombinant Human CD44 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln21-Pro220) of human CD44 (Accession #NP_000601.3) fused with an Fc, 6×His tag at the C-terminus.
Tissue Specificity Detected in fibroblasts and urine (at protein level). Detected in placenta (at protein level). Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
Post Translational Modifications Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. N-glycosylated. O-glycosylated.contains chondroitin sulfate glycans which can be more or less sulfated and whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638. Phosphorylated.activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
Function Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.
Protein Name Cd44 Antigen
Cdw44
Epican
Extracellular Matrix Receptor Iii
Ecmr-Iii
Gp90 Lymphocyte Homing/Adhesion Receptor
Hutch-I
Heparan Sulfate Proteoglycan
Hermes Antigen
Hyaluronate Receptor
Phagocytic Glycoprotein 1
Pgp-1
Phagocytic Glycoprotein I
Pgp-I
Cd Antigen Cd44
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-2160916
Reactome: R-HSA-6798695
Reactome: R-HSA-877300
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Microvillus
Secreted
Colocalizes With Actin In Membrane Protrusions At Wounding Edges
Co-Localizes With Rdx
Ezr And Msn In Microvilli
Localizes To Cholesterol-Rich Membrane-Bound Lipid Raft Domains
Alternative Protein Names Cd44 Antigen protein
Cdw44 protein
Epican protein
Extracellular Matrix Receptor Iii protein
Ecmr-Iii protein
Gp90 Lymphocyte Homing/Adhesion Receptor protein
Hutch-I protein
Heparan Sulfate Proteoglycan protein
Hermes Antigen protein
Hyaluronate Receptor protein
Phagocytic Glycoprotein 1 protein
Pgp-1 protein
Phagocytic Glycoprotein I protein
Pgp-I protein
Cd Antigen Cd44 protein
CD44 protein
LHR protein
MDU2 protein
MDU3 protein
MIC4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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