產(chǎn)品詳情
簡單介紹:
Human CD4 protein (Recombinant) (C-His) (STJP000855)
詳情介紹:
Host: | HEK293 cells |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Recombinant-Human CD4-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: | Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human CD4 Protein at 1 Mu g/mL (100 Mu L/well) can bind CD4 Rabbit mAb with a linear range of 0.006-0.18 ng/mL. |
Gene Symbol: | CD4 |
Gene ID: | 920 |
Uniprot ID: | CD4_HUMAN |
Immunogen Region: | Lys26-Trp390 |
Immunogen: | Recombinant Human sCD4 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Lys26-Trp390) of human sCD4 (Accession #NP_000607.1) fused with a 6×His tag at the C-terminus. |
Tissue Specificity | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells. |
Post Translational Modifications | Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. Phosphorylated by PKC.phosphorylation at Ser-433 plays an important role for CD4 internalization. |
Function | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Down-regulated by HIV-1 Vpu. Acts as a receptor for Human Herpes virus 7/HHV-7. |
Protein Name | T-Cell Surface Glycoprotein Cd4 T-Cell Surface Antigen T4/Leu-3 Cd Antigen Cd4 |
Database Links | Reactome: R-HSA-1462054 Reactome: R-HSA-167590 Reactome: R-HSA-173107 Reactome: R-HSA-180534 Reactome: R-HSA-202424 Reactome: R-HSA-202427 Reactome: R-HSA-202430 Reactome: R-HSA-202433 Reactome: R-HSA-389948 Reactome: R-HSA-449836 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Localizes To Lipid Rafts Removed From Plasma Membrane By Hiv-1 Nef Protein That Increases Clathrin-Dependent Endocytosis Of This Antigen To Target It To Lysosomal Degradation Cell Surface Expression Is Also Down-Modulated By Hiv-1 Envelope Polyprotein Gp160 That Interacts With And Sequesters Cd4 In The Endoplasmic Reticulum |
Alternative Protein Names | T-Cell Surface Glycoprotein Cd4 protein T-Cell Surface Antigen T4/Leu-3 protein Cd Antigen Cd4 protein CD4 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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