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Human CD38 protein (Active Recombinant) (C-His) (STJP000926)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Active Recombinant-Human CD38-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human CD38 Protein at 1 Mu g/mL (100 Mu L/well) can bind CD38 Rabbit pAb with a linear range of 0.244-3.2 ng/mL.2. Loaded CD38 Rabbit mAb (Catalog:A20215) on ProA Biosensor, can bind

Gene Symbol:	CD38
Gene ID:	952
Uniprot ID:	CD38_HUMAN
Immunogen Region:	Val43-Ile300
Immunogen:	Recombinant Human CD38 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val43-Ile300) of human CD38 (Accession #NP_001766.2) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Function	Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity.
Protein Name	Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 2'-Phospho-Adp-Ribosyl Cyclase 2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase 2'-Phospho-Cyclic-Adp-Ribose Transferase Adp-Ribosyl Cyclase 1 Adprc 1 Cyclic Adp-Ribose Hydrolase 1 Cadpr Hydrolase 1 T10 Cd Antigen Cd38
Database Links	Reactome: R-HSA-196807
Cellular Localisation	Cell Surface Membrane Single-Pass Type Ii Membrane Protein
Alternative Protein Names	Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 protein 2'-Phospho-Adp-Ribosyl Cyclase protein 2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase protein 2'-Phospho-Cyclic-Adp-Ribose Transferase protein Adp-Ribosyl Cyclase 1 protein Adprc 1 protein Cyclic Adp-Ribose Hydrolase 1 protein Cadpr Hydrolase 1 protein T10 protein Cd Antigen Cd38 protein CD38 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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