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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human CD163 protein (Recombinant) (C-His & Avi) (STJP002110)

  • 產(chǎn)品型號：STJP002110-100
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human CD163 protein (Recombinant) (C-His & Avi) (STJP002110)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD163-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD163
Gene ID: 9332
Uniprot ID: C163A_HUMAN
Immunogen Region: Ser42-Ser1045
Immunogen: Recombinant Human CD163 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ser42-Ser1045) of Human CD163 fused with a His tag and Avi tag at the C-terminal.
Post Translational Modifications A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.
Function Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Protein Name Scavenger Receptor Cysteine-Rich Type 1 Protein M130
Hemoglobin Scavenger Receptor
Cd Antigen Cd163 Cleaved Into - Soluble Cd163
Scd163
Database Links Reactome: R-HSA-2168880
Reactome: R-HSA-9662834
Cellular Localisation Soluble Cd163: Secreted
Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 1 And Isoform 2 Show A Lower Surface Expression When Expressed In Cells
Alternative Protein Names Scavenger Receptor Cysteine-Rich Type 1 Protein M130 protein
Hemoglobin Scavenger Receptor protein
Cd Antigen Cd163 Cleaved Into - Soluble Cd163 protein
Scd163 protein
CD163 protein
M130 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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