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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human CD14 protein (Recombinant) (C-His) (STJP001089)

  • 產(chǎn)品型號：STJP001089
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human CD14 protein (Recombinant) (C-His) (STJP001089)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD14-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its ability to enhance LPS-stimulated IL-8 secretion by THP-1 human acute monocytic leukemia cells. The ED50 for this effect is 5.7-23 ng/mL.
Gene Symbol: CD14
Gene ID: 929
Uniprot ID: CD14_HUMAN
Immunogen Region: Thr20-Cys352
Immunogen: Recombinant Human CD14 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr20-Cys352) of human CD14 (Accession #NP_000582.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Detected on macrophages (at protein level). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes.also expressed by most tissue macrophages.
Post Translational Modifications N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Protein Name Monocyte Differentiation Antigen Cd14
Myeloid Cell-Specific Leucine-Rich Glycoprotein
Cd Antigen Cd14 Cleaved Into - Monocyte Differentiation Antigen Cd14 - Urinary Form - Monocyte Differentiation Antigen Cd14 - Membrane-Bound Form
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-140534
Reactome: R-HSA-166016
Reactome: R-HSA-166020
Reactome: R-HSA-166058
Reactome: R-HSA-166166
Reactome: R-HSA-168179
Reactome: R-HSA-168188
Reactome: R-HSA-2562578
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5686938
Reactome: R-HSA-6798695
Reactome: R-HSA-936964
Reactome: R-HSA-937041
Reactome: R-HSA-937072
Reactome: R-HSA-975163
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Membrane Raft
Golgi Apparatus
Secreted Forms May Arise By Cleavage Of The Gpi Anchor
Alternative Protein Names Monocyte Differentiation Antigen Cd14 protein
Myeloid Cell-Specific Leucine-Rich Glycoprotein
Cd Antigen Cd14 Cleaved Into - Monocyte Differentiation Antigen Cd14 - Urinary Form - Monocyte Differentiation Antigen Cd14 - Membrane-Bound Form protein
CD14 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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