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產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：Anti-ABCD1 antibody (340-500) (STJ114034)

  • 產(chǎn)品型號(hào)：STJ114034
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-ABCD1 antibody (340-500) (STJ114034)
詳情介紹：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ABCD1 (340-500) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCD1
Gene ID: 215
Uniprot ID: ABCD1_HUMAN
Immunogen Region: 340-500
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 340-500 of human ABCD1 (NP_000024.2).
Immunogen Sequence: SASGLLMVAVPIITATGYSE SDAEAVKKAALEKKEEELVS ERTEAFTIARNLLTAAADAI ERIMSSYKEVTELAGYTARV HEMFQVFEDVQRCHFKRPRE LEDAQAGSGTIGRSGVRVEG PLKIRGQVVDVEQGIICENI PIVTPSGEVVVASLNIRVEE G
Post Translational Modifications Tyrosine-phosphorylated.
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes.namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs.
Protein Name Atp-Binding Cassette Sub-Family D Member 1
Adrenoleukodystrophy Protein
Aldp
Database Links Reactome: R-HSA-1369062
Reactome: R-HSA-2046105
Reactome: R-HSA-2046106
Reactome: R-HSA-390247
Reactome: R-HSA-5684045
Reactome: R-HSA-9603798
Cellular Localisation Peroxisome Membrane
Multi-Pass Membrane Protein
Mitochondrion Membrane
Lysosome Membrane
Endoplasmic Reticulum Membrane
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family D Member 1 antibody
Anti-Adrenoleukodystrophy Protein antibody
Anti-Aldp antibody
Anti-ABCD1 antibody
Anti-ALD antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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