產(chǎn)品詳情
簡單介紹：
ARHGEF7 Positive Control for STJ500159 peptide (STJ503702)
詳情介紹：
| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | ARHGEF7 Positive Control for STJ500159 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | ARHGEF7 |
| Gene ID: | 8874 |
| Uniprot ID: | ARHG7_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with ARHGEF7 antibody STJ500159. |
| Post Translational Modifications | Phosphorylated by PTK2/FAK1.this promotes interaction with RAC1. Phosphorylated on Ser-694 by CaMK1.enhancement of GEF activity and downstream activation of RAC1. |
| Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
| Peptide Name | Rho Guanine Nucleotide Exchange Factor 7 Beta-Pix Cool-1 Pak-Interacting Exchange Factor Beta P85 |
| Database Links | Reactome: R-HSA-182971 Reactome: R-HSA-193648 Reactome: R-HSA-3928664 Reactome: R-HSA-416482 Reactome: R-HSA-8980692 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013406 Reactome: R-HSA-9013409 Reactome: R-HSA-9013420 Reactome: R-HSA-9013424 Reactome: R-HSA-9619229 Q14155-1 |
| Cellular Localisation | Cell Junction Focal Adhesion Cell Projection Ruffle Cytoplasm Cell Cortex Lamellipodium Detected At Cell Adhesions A Small Proportion Is Detected At Focal Adhesions |
| Alternative Peptide Names | Rho Guanine Nucleotide Exchange Factor 7 protein Beta-Pix protein Cool-1 protein Pak-Interacting Exchange Factor Beta protein P85 protein ARHGEF7 protein COOL1 protein KIAA0142 protein P85SPR protein PAK3BP protein PIXB protein Nbla10314 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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