產(chǎn)品詳情
簡單介紹：
Anti-ABCA2 antibody (140-350) (STJ119146)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ABCA2 (140-350) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCA2 |
| Gene ID: | 20 |
| Uniprot ID: | ABCA2_HUMAN |
| Immunogen Region: | 140-350 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-350 of human ABCA2 (NP_001597.2). |
| Immunogen Sequence: | SHLDRSTVSSFSLDSVARNP QELWRFLTQNLSLPNSTAQA LLAARVDPPEVYHLLFGPSS ALDSQSGLHKGQEPWSRLGG NPLFRMEELLLAPALLEQLT CTPGSGELGRILTVPESQKG ALQGYRDAVCSGQAAARARR FSGLSAELRNQLDVAKVSQQ LGLDAPNGSDSSPQAPPPRR LQALLGDLLDAQKVLQDVDV LSALALLLPQG |
| Tissue Specificity | Isoform 3: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver. Isoform 4: Weakly expressed in brain and highly in peripheral blood leukocytes. |
| Post Translational Modifications | Methylated at Gln-271 by N6AMT1. |
| Function | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation. |
| Protein Name | Atp-Binding Cassette Sub-Family A Member 2 Atp-Binding Cassette Transporter 2 Atp-Binding Cassette 2 |
| Database Links | Reactome: R-HSA-1369062 |
| Cellular Localisation | Endosome Membrane Multi-Pass Membrane Protein Lysosome Membrane Forms Discrete Punctate Intracellular Vesicles |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family A Member 2 antibody Anti-Atp-Binding Cassette Transporter 2 antibody Anti-Atp-Binding Cassette 2 antibody Anti-ABCA2 antibody Anti-ABC2 antibody Anti-KIAA1062 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
相關(guān)信息
![Anti-14-3-3 beta/Theta antibody (1-100) [S1MR] (STJ11103651)](http://y1.yzimgs.com/uploads/465546/2024520-20551366.png?imageView2/2/w/200/h/200)
- 細(xì)胞培養(yǎng)玄學(xué)-MRC-5細(xì)胞 2025-01-07
- Ocean NanoTech定制的詳細(xì)步驟 2021-10-31
- click chemistry tools數(shù)據(jù)結(jié)果比... 2021-10-31
- Abbiotec代理的產(chǎn)品得到重復(fù)驗證2020 2021-10-31
- LaysanBio代理商相關(guān)文獻資料2020 2021-10-31
- zyagen Laboratories代理的產(chǎn)品得到... 2021-06-20
- Toxin Technologies代理商相關(guān)文獻資... 2021-03-14
- 熱烈祝賀玉博生物正式代理biocolor公司試劑產(chǎn)品... 2021-03-14
- 熱烈祝賀玉博生物正式代理cytognos公司試劑產(chǎn)品... 2021-03-14
- Gelest代理的產(chǎn)品得到重復(fù)驗證2020 2021-03-14
