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產(chǎn)品詳情

  • 產(chǎn)品名稱：alpha Actinin 4 Blocking Peptide for STJ502088 peptide (STJ503627)

  • 產(chǎn)品型號(hào)：STJ503627-250
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
alpha Actinin 4 Blocking Peptide for STJ502088 peptide (STJ503627)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: alpha Actinin 4 Blocking Peptide for STJ502088 is synthetically produced from the 140-190 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ACTN4
Gene ID: 81
Uniprot ID: ACTN4_HUMAN
Immunogen Region: 140-190
Specificity: This blocking peptide is recommended for use in combination with alpha Actinin 4 antibody, STJ502088
Immunogen: Synthetic peptide taken within amino acid region 140-190 on human Alpha Actinin 4 protein.
Tissue Specificity Widely expressed.
Function F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA.
Peptide Name Alpha-Actinin-4
Non-Muscle Alpha-Actinin 4
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-373753
Cellular Localisation Nucleus
Cytoplasm
Cell Junction
Cytoskeleton
Stress Fiber
Perinuclear Region
Localized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas
Expressed In The Perinuclear Rim And Manchette Structure In Early Elongating Spermatids During Spermiogenesis
Nuclear Translocation Can Be Induced By The Pi3 Kinase Inhibitor Wortmannin Or By Cytochalasin D
Exclusively Localized In The Nucleus In A Limited Number Of Cell Lines (Breast Cancer Cell Line Mcf-7
Oral Floor Cancer Imc-2
And Bladder Cancer Ku-7)
Alternative Peptide Names Alpha-Actinin-4 protein
Non-Muscle Alpha-Actinin 4 protein
ACTN4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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