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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human Brain Natriuretic Peptide/BNP protein (Recombinant) (C-hFC) (STJP002653)

  • 產(chǎn)品型號：STJP002653
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human Brain Natriuretic Peptide/BNP protein (Recombinant) (C-hFC) (STJP002653)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Brain Natriuretic Peptide/BNP-C-hFC protein was developed from hek293 cells and has a target region of C-hFC. For use in research applications.
Formulation: Lyophilized from a 0.2 Mu m filtered solution of PBS, pH7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NPPB
Gene ID: 4879
Uniprot ID: ANFB_HUMAN
Immunogen Region: His27-Pro104
Immunogen: Recombinant Human Brain Natriuretic Peptide/BNP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (His27-Pro104) of human Brain Natriuretic Peptide/BNP (Accession #P16860) fused with a hFC tag at the
Post Translational Modifications The precursor molecule is proteolytically cleaved by the endoproteases FURIN or CORIN at Arg-102 to produce brain natriuretic peptide 32 and NT-proBNP. This likely occurs after it has been secreted into the blood, either during circulation or in the target cells. CORIN also cleaves the precursor molecule at additional residues including Arg-99 and possibly Lys-105. In patients with heart failure, processing and degradation of natriuretic peptides B occurs but is delayed, possibly due to a decrease in enzyme level or activity of CORIN and DPP4. Brain natriuretic peptide 32: Undergoes further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides. Cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Degraded by IDE. During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro). O-glycosylated on at least seven residues. In cardiomyocytes, glycosylation at Thr-97 is essential for the stability and processing of the extracellular natriuretic peptides B. Glycosylation, especially at Thr-97, may also be important for brain natriuretic peptide 32 stability and/or extracellular distribution. Glycosylation at Thr-97 appears to inhibit FURIN- or CORIN-mediated proteolytic processing, at least in HEK293 cells.
Function Brain natriuretic peptide 32: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3. NT-proBNP: May affect cardio-renal homeostasis. Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32. BNP(3-32): May have a role in cardio-renal homeostasis. Able to promote the production of cGMP.
Protein Name Natriuretic Peptides B
Brain Natriuretic Factor Prohormone
Preprobnp
Probnp
Gamma-Brain Natriuretic Peptide
Iso-Anp Cleaved Into - Nt-Probnp
Nt-Pro-Bnp
Nt-Probnp(1-76 - Probnp(3-108 - Brain Natriuretic Peptide 32
Bnp(1-32
Bnp-32
Brain Natriuretic Peptide
Bnp - Bnp(1-30 - Bnp(1-29 - Bnp(1-28 - Bnp(2-31 - Bnp(3-32
Des-Serpro-Bnp
Probnp(79-108 - Bnp(3-30 - Bnp(3-29 - Brain Natriuretic Peptide 29
Bnp(4-32 - Bnp(4-31 - Bnp(4-30 - Bnp(4-29 - Bnp(4-27 - Bnp(5-32 - Bnp(5-31 - Bnp(5-29
Cellular Localisation Nt-Probnp: Secreted
Detected In Blood
Probnp(3-108): Secreted
Brain Natriuretic Peptide 32: Secreted
Bnp(3-32): Secreted
Alternative Protein Names Natriuretic Peptides B protein
Brain Natriuretic Factor Prohormone protein
Preprobnp protein
Probnp protein
Gamma-Brain Natriuretic Peptide protein
Iso-Anp Cleaved Into - Nt-Probnp protein
Nt-Pro-Bnp protein
Nt-Probnp(1-76 - Probnp(3-108 - Brain Natriuretic Peptide 32 protein
Bnp(1-32 protein
Bnp-32 protein
Brain Natriuretic Peptide protein
Bnp - Bnp(1-30 - Bnp(1-29 - Bnp(1-28 - Bnp(2-31 - Bnp(3-32 protein
Des-Serpro-Bnp protein
Probnp(79-108 - Bnp(3-30 - Bnp(3-29 - Brain Natriuretic Peptide 29 protein
Bnp(4-32 - Bnp(4-31 - Bnp(4-30 - Bnp(4-29 - Bnp(4-27 - Bnp(5-32 - Bnp(5-31 - Bnp(5-29 protein
NPPB protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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