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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human BMPR-2 protein (Recombinant) (C-hFc) (STJP001413)

  • 產(chǎn)品型號(hào)：STJP001413
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Human BMPR-2 protein (Recombinant) (C-hFc) (STJP001413)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human BMPR-2-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human BMP2 at 1 Mu g/mL (100 Mu L/well) can bind Human BMPR2 with a linear range of 19.5 ng/ml-1.46 Mu g/ml.
Gene Symbol: BMPR2
Gene ID: 659
Uniprot ID: BMPR2_HUMAN
Immunogen: Recombinant Human BMPR-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ile151) of human BMPR2 (Accession #NP_001195.2) fused with a hFc tag at the C-terminus.
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Protein Name Bone Morphogenetic Protein Receptor Type-2
Bmp Type-2 Receptor
Bmpr-2
Bone Morphogenetic Protein Receptor Type Ii
Bmp Type Ii Receptor
Bmpr-Ii
Database Links Reactome: R-HSA-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Bone Morphogenetic Protein Receptor Type-2 protein
Bmp Type-2 Receptor protein
Bmpr-2 protein
Bone Morphogenetic Protein Receptor Type Ii protein
Bmp Type Ii Receptor protein
Bmpr-Ii protein
BMPR2 protein
PPH1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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