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產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：BMP11 Positive Control peptide (STJ503749)

  • 產(chǎn)品型號(hào)：STJ503749-5
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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BMP11 Positive Control peptide (STJ503749)
詳情介紹：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: BMP11 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GDF11
Gene ID: 10220
Uniprot ID: GDF11_HUMAN
Tissue Specificity In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme.
Post Translational Modifications Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases. This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase.
Function Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.
Peptide Name Growth/Differentiation Factor 11
Gdf-11
Bone Morphogenetic Protein 11
Bmp-11
Cellular Localisation Secreted
Alternative Peptide Names Growth/Differentiation Factor 11 protein
Gdf-11 protein
Bone Morphogenetic Protein 11 protein
Bmp-11 protein
GDF11 protein
BMP11 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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