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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ABI2 antibody (100-200) (STJ117190)

  • 產(chǎn)品型號(hào)：STJ117190
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-ABI2 antibody (100-200) (STJ117190)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ABI2 (100-200) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABI2
Gene ID: 10152
Uniprot ID: ABI2_HUMAN
Immunogen Region: 100-200
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABI2 (NP_001269854.1).
Immunogen Sequence: HKEKVARREIGILTTNKNTS RTHKIIAPANLERPVRYIRK PIDYTILDDIGHGVKWLLRF KVSTQNMKMGGLPRTTPPTQ KPPSPPMSGKGTLGRHSPYR T
Tissue Specificity Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen.
Post Translational Modifications Phosphorylated by ABL1.
Function Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface. Also required for nascent adherens junction assembly in epithelial cells.
Protein Name Abl Interactor 2
Abelson Interactor 2
Abi-2
Abl-Binding Protein 3
Ablbp3
Arg-Binding Protein 1
Argbp1
Database Links Reactome: R-HSA-2029482
Reactome: R-HSA-4420097
Reactome: R-HSA-5663213
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013423
Reactome: R-HSA-9664422
Cellular Localisation Cytoplasm
Nucleus
Isoform 1: Cell Projection
Lamellipodium
Cell Projection
Filopodium
Cytoskeleton
Cell Junction
Adherens Junction
Isoform 1 But Not Isoform 3 Is Localized To Protruding Lamellipodia And Filopodia Tips
Present At Nascent Adherens Junctions
Where It Clusters Adjacent To The Tips Of F-Actin Protrusions
Alternative Antibody Names Anti-Abl Interactor 2 antibody
Anti-Abelson Interactor 2 antibody
Anti-Abi-2 antibody
Anti-Abl-Binding Protein 3 antibody
Anti-Ablbp3 antibody
Anti-Arg-Binding Protein 1 antibody
Anti-Argbp1 antibody
Anti-ABI2 antibody
Anti-ARGBPIA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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