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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ABI1 antibody (152-201 aa) (STJ91430)

  • 產(chǎn)品型號：STJ91430
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-ABI1 antibody (152-201 aa) (STJ91430)
詳情介紹：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Abl interactor 1 (152-201 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABI1
Gene ID: 10006
Uniprot ID: ABI1_HUMAN
Immunogen Region: 152-201 aa
Specificity: Abi-1 Polyclonal Antibody detects endogenous levels of Abi-1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Abi-1 at the amino acid range 152-201
Post Translational Modifications Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization.
Function May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Protein Name Abl Interactor 1
Abelson Interactor 1
Abi-1
Abl-Binding Protein 4
Ablbp4
Eps8 Sh3 Domain-Binding Protein
Eps8-Binding Protein
Nap1-Binding Protein
Nap1bp
Spectrin Sh3 Domain-Binding Protein 1
E3b1
Database Links Reactome: R-HSA-2029482
Reactome: R-HSA-4420097
Reactome: R-HSA-5663213
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013423
Reactome: R-HSA-9664422
Cellular Localisation Cytoplasm
Nucleus
Cell Projection
Lamellipodium
Filopodium
Growth Cone
Postsynaptic Density
Cytoskeleton
Localized To Protruding Lamellipodia And Filopodia Tips
Also Localized To Neuronal Growth Cones And Synaptosomes
May Shuttle From The Postsynaptic Densities To The Nucleus
Alternative Antibody Names Anti-Abl Interactor 1 antibody
Anti-Abelson Interactor 1 antibody
Anti-Abi-1 antibody
Anti-Abl-Binding Protein 4 antibody
Anti-Ablbp4 antibody
Anti-Eps8 Sh3 Domain-Binding Protein antibody
Anti-Eps8-Binding Protein antibody
Anti-Nap1-Binding Protein antibody
Anti-Nap1bp antibody
Anti-Spectrin Sh3 Domain-Binding Protein 1 antibody
Anti-E3b1 antibody
Anti-ABI1 antibody
Anti-SSH3BP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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