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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human Angiopoietin-2 protein (Recombinant) {Biotin} (STJP000188)

  • 產(chǎn)品型號(hào)：STJP000188
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Human Angiopoietin-2 protein (Recombinant) {Biotin} (STJP000188)
詳情介紹：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Angiopoietin-2-protein was developed from hek293. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for twelve months. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/μg (1EU/μg). NA
Immunoreactivity: The activity was tested by the ability of immobilized recombinant Human Tie2 to bind biotinylated recombinant human Angiopoietin-2 in ELISA NA
Gene Symbol: ANGPT2
Gene ID: 285
Uniprot ID: ANGP2_HUMAN
Immunogen Region: TYR19-PHE496
Immunogen: Optimized DNA sequence encoding extracellular domain of Human Angiopoietin-2 (TYR19-PHE496) including a C-terminal His tag was expressed in HEK293 cells. Recombinant Angiopoietin-2 was further labled by Biotin for detection by avidin conjugated secon
Function Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.
Protein Name Angiopoietin-2
Ang-2
Database Links Reactome: R-HSA-210993
Cellular Localisation Secreted
Alternative Protein Names Angiopoietin-2 protein
Ang-2 protein
ANGPT2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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