產(chǎn)品詳情
簡(jiǎn)單介紹:
Anti-ABCC6 antibody (830-940) (STJ110399)
詳情介紹:
Host: | Rabbit |
Applications: | WB |
Reactivity: | Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-ABCC6 (830-940) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ABCC6 |
Gene ID: | 368 |
Uniprot ID: | MRP6_HUMAN |
Immunogen Region: | 830-940 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 830-940 of human ABCC6 (NP_001162.4). |
Immunogen Sequence: | AIAEMGSYQELLQRKGALVC LLDQARQPGDRGEGETEPGT STKDPRGTSAGRRPELRRER SIKSVPEKDRTTSEAQTEVP LDDPDRAGWPAGKDSIQYGR VKATVHLAYLR |
Tissue Specificity | Expressed in kidney and liver. Very low expression in other tissues. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules. |
Post Translational Modifications | Glycosylated. |
Function | Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. |
Protein Name | Atp-Binding Cassette Sub-Family C Member 6 Anthracycline Resistance-Associated Protein Multi-Specific Organic Anion Transporter E Moat-E Multidrug Resistance-Associated Protein 6 |
Database Links | Reactome: R-HSA-382556 Reactome: R-HSA-5690338 |
Cellular Localisation | Basal Cell Membrane Multi-Pass Membrane Protein Localized To The Basal Membrane Of Sertoli Cells Isoform 1: Basolateral Cell Membrane Isoform 2: Endoplasmic Reticulum Membrane Single-Pass Membrane Protein |
Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 6 antibody Anti-Anthracycline Resistance-Associated Protein antibody Anti-Multi-Specific Organic Anion Transporter E antibody Anti-Moat-E antibody Anti-Multidrug Resistance-Associated Protein 6 antibody Anti-ABCC6 antibody Anti-ARA antibody Anti-MRP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
相關(guān)信息

- 細(xì)胞培養(yǎng)玄學(xué)-MRC-5細(xì)胞 2025-01-07
- Ocean NanoTech定制的詳細(xì)步驟 2021-10-31
- Abbiotec代理的產(chǎn)品得到重復(fù)驗(yàn)證2020 2021-10-31
- LaysanBio代理商相關(guān)文獻(xiàn)資料2020 2021-10-31
- click chemistry tools數(shù)據(jù)結(jié)果比... 2021-10-31
- zyagen Laboratories代理的產(chǎn)品得到... 2021-06-20
- Toxin Technologies代理商相關(guān)文獻(xiàn)資... 2021-03-14
- 熱烈祝賀玉博生物正式代理biocolor公司試劑產(chǎn)品... 2021-03-14
- 熱烈祝賀玉博生物正式代理cytognos公司試劑產(chǎn)品... 2021-03-14
- Gelest代理的產(chǎn)品得到重復(fù)驗(yàn)證2020 2021-03-14