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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ABCC6 antibody (830-940) (STJ110399)

  • 產(chǎn)品型號(hào)：STJ110399
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Anti-ABCC6 antibody (830-940) (STJ110399)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ABCC6 (830-940) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCC6
Gene ID: 368
Uniprot ID: MRP6_HUMAN
Immunogen Region: 830-940
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 830-940 of human ABCC6 (NP_001162.4).
Immunogen Sequence: AIAEMGSYQELLQRKGALVC LLDQARQPGDRGEGETEPGT STKDPRGTSAGRRPELRRER SIKSVPEKDRTTSEAQTEVP LDDPDRAGWPAGKDSIQYGR VKATVHLAYLR
Tissue Specificity Expressed in kidney and liver. Very low expression in other tissues. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules.
Post Translational Modifications Glycosylated.
Function Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.
Protein Name Atp-Binding Cassette Sub-Family C Member 6
Anthracycline Resistance-Associated Protein
Multi-Specific Organic Anion Transporter E
Moat-E
Multidrug Resistance-Associated Protein 6
Database Links Reactome: R-HSA-382556
Reactome: R-HSA-5690338
Cellular Localisation Basal Cell Membrane
Multi-Pass Membrane Protein
Localized To The Basal Membrane Of Sertoli Cells
Isoform 1: Basolateral Cell Membrane
Isoform 2: Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family C Member 6 antibody
Anti-Anthracycline Resistance-Associated Protein antibody
Anti-Multi-Specific Organic Anion Transporter E antibody
Anti-Moat-E antibody
Anti-Multidrug Resistance-Associated Protein 6 antibody
Anti-ABCC6 antibody
Anti-ARA antibody
Anti-MRP6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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