產(chǎn)品詳情
簡(jiǎn)單介紹:
Axin 2 Blocking Peptide peptide (STJ503690)
詳情介紹:
Applications: | Immunodepletion/Immunocompetition |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Axin 2 Blocking Peptide is synthetically produced from the 800-843 sequence and is suitable for use in western blot applications. |
Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | AXIN2 |
Gene ID: | 8313 |
Uniprot ID: | AXIN2_HUMAN |
Immunogen Region: | 800-843 |
Immunogen: | Synthetic peptide taken within amino acid region 800-843 on human Axin 2 protein. |
Tissue Specificity | Expressed in brain and lymphoblast. |
Post Translational Modifications | Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. |
Function | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. |
Peptide Name | Axin-2 Axin-Like Protein Axil Axis Inhibition Protein 2 Conductin |
Database Links | Reactome: R-HSA-201681 Reactome: R-HSA-4411364 Reactome: R-HSA-4641257 Reactome: R-HSA-5689880 |
Cellular Localisation | Cytoplasm |
Alternative Peptide Names | Axin-2 protein Axin-Like Protein protein Axil protein Axis Inhibition Protein 2 protein Conductin protein AXIN2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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