產(chǎn)品詳情
簡(jiǎn)單介紹：
DNase I protein (STJP000146)
詳情介紹：
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | DNase I-protein was developed from. For use in research applications. |
| Formulation: | PBS pH 7.4 |
| Purification: | Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media |
| Concentration: | 0.5 mg/ml |
| Storage Instruction: | Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
| Gene Symbol: | DNASE1 |
| Gene ID: | 1773 |
| Uniprot ID: | DNAS1_HUMAN |
| Tissue Specificity | Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva. |
| Function | Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation. |
| Protein Name | Deoxyribonuclease-1 Deoxyribonuclease I Dnase I Dornase Alfa |
| Cellular Localisation | Secreted Zymogen Granule Nucleus Envelope Secretory Protein Stored In Zymogen Granules And Found In The Nuclear Envelope |
| Alternative Protein Names | Deoxyribonuclease-1 protein Deoxyribonuclease I protein Dnase I protein Dornase Alfa protein DNASE1 protein DNL1 protein DRNI protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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