產(chǎn)品詳情
簡單介紹：
Anti-ABCB7 antibody (503-753) (STJ116899)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ABCB7 (503-753) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCB7 |
| Gene ID: | 22 |
| Uniprot ID: | ABCB7_HUMAN |
| Immunogen Region: | 503-753 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 503-753 of human ABCB7 (NP_004290.2). |
| Immunogen Sequence: | AIVGGSGSGKSTIVRLLFRF YEPQKGSIYLAGQNIQDVSL ESLRRAVGVVPQDAVLFHNT IYYNLLYGNISASPEEVYAV AKLAGLHDAILRMPHGYDTQ VGERGLKLSGGEKQRVAIAR AILKDPPVILYDEATSSLDS ITEETILGAMKDVVKHRTSI FIAHRLSTVVDADEIIVLDQ GKVAERGTHHGLLANPHSIY SEMWHTQSSRVQNHDNPKWE AKKENISKEEERKKLQEEI |
| Function | Exports glutathione-coordinated iron-sulfur clusters such as 2Fe-2S-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1. May also play a role in hematopoiesis. |
| Protein Name | Iron-Sulfur Clusters Transporter Abcb7 - Mitochondrial Atp-Binding Cassette Sub-Family B Member 7 - Mitochondrial Atp-Binding Cassette Transporter 7 Abc Transporter 7 Protein |
| Database Links | Reactome: R-HSA-1369007 Reactome: R-HSA-2564830 |
| Cellular Localisation | Mitochondrion Inner Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Iron-Sulfur Clusters Transporter Abcb7 - Mitochondrial antibody Anti-Atp-Binding Cassette Sub-Family B Member 7 - Mitochondrial antibody Anti-Atp-Binding Cassette Transporter 7 antibody Anti-Abc Transporter 7 Protein antibody Anti-ABCB7 antibody Anti-ABC7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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